The Best Hyaluronic Acid Serum For Your Face

It’s described as ‘the fountain of youth’ and is considered by many people to be the most important anti-aging treatment if you are looking to regain youthful, plump, and firm skin.

Its rejuvenating properties are not in any doubt, a considerable body of scientific research proves the positive benefits it has for your skin.

But there’s one problem…

Hyaluronic acid brands are easy to find, but not all of them are created equal.

There are some important things you should know when you are looking for the best hyaluronic acid serum for your face.

In our buying guide below we’ve explained the essential things to look for in an effective serum.

And then, in our hyaluronic acid serum reviews, we’ve carefully selected our top 5 favorites that will work wonders on your skin.

Why You Should Use A Hyaluronic Acid Serum

The Best Hyaluronic Acid Serum For Face

Hyaluronic acid is a naturally occurring molecule in your skin that is largely responsible for maintaining a high moisture content by binding and holding water.

It can hold 1000 times its own weight in water, with 1g having the capacity to hold 6 liters.

When you are very young your body produces enough hyaluronic acid to meet your needs and keep your skin looking plump and fresh (1).

Sadly, as you age your production of hyaluronic acid slowly declines. By the time you are in your 40s the amount of it being produced will have halved.

This means that as you age you have less and less hyaluronic acid in your skin.

This is one of the main reasons for skin aging and the formation of wrinkles, lines, and sagging.

Fortunately, using an effective serum can help to replace some of the hyaluronic acid that you lose (2).

Not only does this help to prevent the visible signs of aging on your face, but it can also help to reverse them, giving you soft and smooth skin.

Using a hyaluronic acid serum has a number of scientifically proven benefits for your skin health:

  • It moisturizes the skin
  • It reduces lines and wrinkles
  • It increases skin elasticity
  • It stimulates collagen production
  • It improves areas of rough skin
  • It can successfully treat skin conditions such as rosacea and dermatitis


Choosing A Hyaluronic Acid Serum – Things To Consider


The Type Of Hyaluronic Acid And The Molecular Weight

Hyaluronic Acid

Hyaluronic acid in its natural form is a very large molecule. But this size means that when it is used in skin care preparations it has difficulty in penetrating into the skin.

This hyaluronic acid, with a high molecular weight, mostly sits on the surface of your skin rather than being absorbed.

When applied topically, it still acts as a good moisturizer, but it will not give you the full range of benefits that come when it is able to get inside your skin in sufficient quantity.

You will find that a lot of hyaluronic acid serums at the cheaper end of the market contain this in the list of ingredients.

If it is just listed as hyaluronic acid in the ingredients, then it is probably high molecular weight.

Sodium Hyaluronate

This is the sodium salt of hyaluronic acid. During the process of making sodium hyaluronate it is possible to decrease the molecular weight by removing excess proteins, lipids, and nucleic acids.

The result is a much smaller molecule than regular hyaluronic acid, that has better penetration into the skin.

This is more useful for skin care formulations as the effects of using the product are greater.



Typically, hyaluronic acid is used in concentrations between 0.1-2%, with it rarely exceeding 2%. Anything more than 4% is not desirable, as at higher concentrations it can actually be drying for your skin.

Concentrations of 0.1%-2% have proved effective in studies.

You might see some products that claim they have 100% pure hyaluronic acid, or 70% etc, but that doesn't refer to the concentration in the final product. 100% pure is mixed with water or it would be a rock.


The Best Hyaluronic Acid Serum For Face Reviews

Because of the range of brands available, finding the best hyaluronic acid serum can be difficult for buyers. So here we provide a review of the best products on the market.

Because of the increased biological effectiveness of low molecular weight hyaluronic acid serums, we have selected serums that use sodium hyaluronate.

Skinceuticals Hydrating B5 Gel

The Skinceuticals brand is highly respected for their range of high quality and effective skin care products.

The Hydrating B5 Gel contains sodium hyaluronate at a 2% concentration and is made in the USA.

It is combined with one other complementary active ingredient:

  • Vitamin B5 

    This water soluble vitamin easily penetrates deep into the skin where it acts as a humectant, binding water and moisturizing the skin.

    When it is applied regularly it also acts as an anti-inflammatory and soothes dry and itchy skin. It is also helps chapped lips.

This product is often recommended by dermatologists to patients, and it has a reputation for its effectiveness at hydrating dry skin.

It is ideal for oily, dry, combination, normal, and sensitive skin types.

It is a good choice for people who want a hyaluronic acid serum without all the additional botanic and chemical ingredients that are put in other anti-aging serums.


Vernal Skincare Hyaluronic Acid Serum

This anti-aging hyaluronic acid serum from Vernal Skincare uses sodium hyaluronate at a 2% concentration.

It is made in the USA without the use of parabens and sulfates, and using 100% pure lab certified products.

It contains several other active ingredients that work together:

  • Witch Hazel Extract

Witch hazel helps to moisturize the skin, and reduce the size of skin pores.

It's also an anti-inflammatory, and antibacterial, that is an effective natural remedy for acne, psoriasis and eczema.

  • Lavender Oil

Lavender oil is another anti-inflammatory and antibacterial, that prevents the formation of acne and can be used in the treatment of psoriaisi and eczema.

It is also an antioxidant that offers protection against the damaging effects of ultraviolet rays.

  • L-Arginine

L-arginine is an essential amino acid that acts as a moisturizer and antioxidant that helps to build collagen in the skin, and promotes skin elasticity.

  • Aloe Barbadensis

Also known as Aloe vera. Well known for its moisturizing capabilities, aloe also has antibacterial properties and contains antioxidants that protect the skin from oxidative damage.

  • Tocopheryl Acetate

Tocopheryl is vitamin E. It is an antioxidant that protects the skin from sun damage and increases skin hydration.

  • Tetrahexyldecyl Ascorbate

This is a vitamin C derivative. It is absorbed by the skin where it acts as a powerful antioxidant, protecting the skin from ultraviolet radiation. It also stimulates the production of new collagen which reduces fine lines and wrinkles.

  • Retinyl Palmitate

This provides retinol (vitamin A) to your skin. It can help to reduce lines and wrinkles due to its ability to stimulate collagen production and cellular regeneration.

Significant results are common within the first month of using this product, with firmer, smoother, and well moisturized skin being visible to the eye.

It effectively reduces people’s lines and wrinkles, and improves skin texture, leaving a radiant and glowing skin.


ResQ Organics Night Serum With Manuka Honey

This serum from ResQ Organics uses sodium hyaluronate of a low molecular weight, which increases its ability to penetrate the skin.

It has a hyaluronic acid concentration of 2% and is made in the USA, containing no alcohol, parabens, or fragrances

It is suitable for vegans as no animal products or testing has gone into this serum.

This serum combines a number of natural active ingredients that have anti-aging properties:

  • Manuka Honey

Produced by the bees that feed on the Manuka shrub on New Zealand's North Island, this has the ability to protect and promote collagen production, soothe inflammation, moisturize, and heal blemishes on the skin.

  • Cehami

Taken from an Australian flower that has been used for centuries by the Aboriginal people for its ability to increase cell regeneration, act as an antimicrobial, and for its anti-inflammatory properties.

  • Sodium Ascorbate

This is the sodium salt of vitamin C (see Vernal Skincare above)

  • Aloe Vera Gel

Soothes and moisturizes skin (see Vernal Skincare above)

  • Retinyl Palmitate

Vitamin A (see Vernal Skincare above)

  • Tocopherol Acetate

Vitamin E (see Vernal Skincare above)

This highly effective blend of anti-aging ingredients has been a big hit with consumers, with many people in love with how it makes their skin look and feel, and the speed with which noticeable results can be seen.

It also comes with a 100% satisfaction guarantee. If you are not happy with this product for any reason you can return it and be refunded.


Lilian Fache Hyaluronic Acid Serum

Lilian Fache Hyaluron Topical Serum uses sodium hyaluronate at a 1% concentration.

It also contains the following active ingredients:

  • Glycerin

This is a humectant that attracts water and helps to moisturize the skin.

  • Aloe Vera

(See Vernal Skincare above)

  • Tocopherol Acetate

Vitamin E (see Vernal Skincare above)

  • Ascorbic Acid

Vitamin C (see Vernal Skincare above)

  • Retinol Palmitate

Vitamin A (see Vernal Skincare above)

This hyaluronic serum has many satisfied customers. It fills in crow’s feet and helps to remove fine facial lines.

It makes skin feel smooth and soft and results appear for some people in as little as three weeks.

The serum has no scent, so it is suitable for people who are sensitive to that type of thing.


CSCS Advanced Face Serum

The CSCS brand uses 2% sodium hyaluronate in its serum.

It’s an all-natural serum that is suitable for vegans and made in a cruelty-free, eco-friendly environment in the USA.

There are no parabens, sulfates, or alcohol in this bottle.

Added ingredients in the formula:

  • Ascorbic Acid

It contains 20% Vitamin C (see ResQ Organics above).

This product is rich in the antioxidant vitamin C, which provides protection against photodamage, and reduces lines and wrinkles by stimulating collagen growth, firming the skin.

It works well with acne medications, anti-aging products, and sunscreens.

It’s well tolerated by all skin types, even sensitive skin, and successfully moisturizes and improves skin firmness and tone when used regularly.

It’s good for the face and under the eyes.



It is best to keep your hyaluronic acid serum in a cool, dark place to maximize its shelf life. Some people like to keep serums like this in the fridge.


Is Hyaluronic Acid Serum Safe? – Side Effects

Hyaluronic acid is very safe, and very few people report skin irritation from using it. Where irritation does occur, it is likely to be caused by the added ingredients that are included in the preparation.

Before using on your face you should consider doing a quick test on the back of your wrist. Apply a small amount of the serum and leave it for 20 minutes. If no irritation occurs then proceed to using it on your face.



Hyaluronic acid plays a proven role in keeping your skin moisturized, and its loss as you age is one of the most important factors in the appearance of lines and wrinkles on your face and neck.

Fortunately, you can replace some of it and reverse the aging process by using a well-formulated beauty serum.

But, if you want the full effects of replenishing the lost hyaluronic acid in your skin it is important to select a serum that has a low enough molecular weight to penetrate.

In our list of favorites, we have only included low molecular weight serums.

We have also included preparations with many other complementary active ingredients, and those that have fewer ingredients for people who want a serum that is mostly about the hyaluronic acid.

The best hyaluronic acid serum for your face in our opinion can be seen on Amazon here:

What hyaluronic acid serum has worked for you? Let us know in the comments below!

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